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For example, a retrospective study of more than one million adults with type 2 diabetes in the United States [median age of 65 years, diabetes duration of 4 years and glycated haemoglobin (HbA1c 6.8%)] reported that 82% had hypertension, 78% had obesity or overweight, 24% had chronic kidney disease and 22% cardiovascular disease

This explains why weight loss with retatrutide dose escalation to 12mg exceeds what appetite suppression alone can account for

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Cheaper medications producing less weight loss may actually cost more per pound achieved