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The relationship between timing and side effects is not definitively established in clinical trials, as most studies do not systematically compare morning versus evening administration

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Trends Endocrinol Metab 22:2433 Tiano JP, Delghingaro-Augusto V, Le May C et al (2011) Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents beta cell failure in rodent models of type 2 diabetes

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