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The final step of DNL is the conversion of malonyl-CoA into palmitate (16:0) by fatty acid synthase (FAS)

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While no specific guidelines exist for MC4R -deficient patients, extrapolating from osteoporosis management principles suggests that baseline dual-energy X-ray absorptiometry (DXA) assessment may be reasonable in individuals with additional fracture risk factors or those anticipating substantial and sustained weight loss [72]

Specifically, the consumption of diet with high fatty acids content negatively affected the quantity of the catalytic subunit of glutamate cysteine ligase (Gcl-c), coding for the rate limiting enzyme of glutathione synthesis, both after saline and APAP injection (Fig