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As a practical guide: if gastrointestinal symptoms persist beyond two to four weeks at a stable dose, are significantly affecting your ability to eat, drink, or carry out daily activities, or are causing signs of dehydration, you should contact your prescriber rather than waiting for symptoms to resolve on their own

Thus, resistance to anti-VEGF drugs in advanced-stage breast cancer may be explained by the dominance of FGF-2 and other pro-angiogenic factors in such stage of the disease (Schneider and Miller, 2005)

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