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Preservation of Muscle and Bone Mass The adverse effects of weight reduction on muscle and bone massparticularly among individuals with insufficient physical activity or protein intake or at older ages 63,158 have highlighted the interrelated priorities to preserve muscle mass, muscle quality, bone mass, and physical function

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Naltrexone may mask opioid-related side effects and carries a black-box warning for potential hepatotoxicity at higher doses, mandating periodic liver function tests

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