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As decreasing glucose levels and alcohol-seeking behavior are 2 dual effects of GLP-1 receptor agonists, the dosage can be adjusted accordingly to achieve the desired benefits while reducing the potential side effects of the drug class

Oprah Winfrey and LongTerm Weight Management With GLP1 Medication Another widely cited disclosure came from Oprah Winfrey, whose experience has been referenced frequently in coverage of GLP1 celebrity weight loss

A third incretin-based approach is tirzepatide, a dual agonist of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR), which achieves greater HbA1c reduction and weight loss compared with GLP-1RAs alone

Kidney Int 2024;105:132-49.ArticlePubMed 128

The researchers observed similar results in the STEP 5 trial