Tirzepatide can cause gastrointestinal changes that increase fluid loss
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While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)
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In considering the benefits and risks of using semaglutide for asthma patients, its clear that while semaglutide can offer significant benefits, such as better blood sugar control and weight loss, these must be weighed against any potential risks to respiratory health