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Despite this, UK guidelines and manufacturers state that GLP-1 medications should not be used by anyone with a personal or family history of Medullary Thyroid Cancer or a rare genetic condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Both are likely to require either significant real world observation in off-label use, or some form of RCT with careful observation

Severe skin reactions, though rare, can be more troublesome and may necessitate discontinuation of the medication

It can lead to stress, anxiety, and even depression

While the measurement isnt perfect, its a useful tool for guiding treatment