Blher M, Aras M, Aronne LJ, et al
(121) published in 2024 revealed a novel mechanism by which AhR, as a uremic toxin receptor, promotes renal senescence and fibrosis: IS upregulates and activates AhR in renal tubular epithelial cells, and AhR can interact with peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1), promoting its ubiquitin-mediated degradation through its E3 ubiquitin ligase activity, thereby inhibiting mitochondrial biogenesis
Leckstrom, A., Bjorklund, K., Permert, J., Larsson, R
H.ScheltensP.AisenP.AndrieuS.et al (2016)
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