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It's important to note that increased urination is not listed as a recognised side effect in the official MHRA/EMC Summaries of Product Characteristics (SmPCs) for these medications

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So when estrogen levels are going down, this isn't happening in early perimenopause, but it is happening in the later half

GSH is also important in detoxification as it is used to conjugate a wide variety of exogenous compounds including carcinogens, toxins and drugs and endogenous electrophiles

Paez-Pereda M, Kovalovsky D, Hopfner U, Theodoropoulou M, Pagotto U, Uhl E, Losa M, Stalla J, Grubler Y, Missale C, Arzt E, Stalla GK