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Why PT-141 Causes Nausea in Some Users PT-141related nausea occurs due to central activation of melanocortin receptors that influence both sexual arousal and autonomic nervous system responses

When a supplement isn't designed for high bioavailability, the unabsorbed nutrients sit in the digestive tract and can cause irritation or an osmotic effect that leads to loose stools

Additionally, tirzepatide suppresses glucagon secretion, slows gastric emptying, and promotes satiety through central nervous system pathways that regulate appetite