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The gradient started at 5% B (held for 2.5 min) and was linearly increased to 30% B within 37.5 min, to 50% B within 10 min, then to 85% B within 5 min (held for 3 min)

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However, it was found that MOTS-c activates AMPK and that MOTS-c downregulates RANKL and upregulates OPG to inhibit osteoclastogenesis (Yan et al., 2019)

Adhesions can also obliterate normal pelvic angles and induce abnormal uterine flexion, while nodularity and thickening of pelvic ligaments (uterosacral ligaments) with fibrotic reactions further disrupt pelvic anatomy ( Mechanically, these changes impair fertility through multiple pathways: extensive adhesions can occlude the tubal ostium and embed ovaries, blocking sperm passage and oocyte release

Peng S, Lin A, Jiang A, Zhang C, Zhang J, Cheng Q, et al