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Secondly, the in vivo distribution and pharmacokinetics of these agents are complex, and clinical trials often encounter issues such as uneven drug retention and dose-limiting toxicities, which remain critical barriers to practical application (137, 138)

Ipamorelin Ipamorelin is a selective growth hormone releasing peptide (GHRP), a synthetic pentapeptide that binds to the ghrelin receptor (GHS-R1a) in the pituitary gland, triggering the release of growth hormone (GH)