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The process is initiated when ROS abstract a hydrogen atom from the methylene group of a PUFA, creating a lipid radical

While this study demonstrated the potential benefits of GSH augmentation in an elderly cohort, a future study design utilizing direct or indirect GSH level measurement in larger and more heterogeneous populations could be undertaken to more precisely identify which patients may benefit from such therapy while sparing others who may have sufficient levels of GSH from unnecessary intervention

267,268 SIRT6, on the other hand, maintains genome integrity during tumorigenesis

Glutathione, the body's master antioxidant and a vital actor in different physiological processes, has a wide-ranging impact on health beyond the skin

Its effect exhibits a dose-dependently increase, and high dose radiation (HDR) has been utilized for eliminating inoperable cancer cells and keloid scars in patients (Rdel et al., 2017)