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Adverse events were reported in a subset of studies, but there was insufficient evidence to determine any association between adverse events during treatment and subsequent weight regain

Receptor occupancy is an important target engagement biomarker for the therapeutic effect for dual acting agonists

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Second, the data from AMPLITUDE-O improved the certainty about the effect of GLP-1 receptor agonists on hospital admission for heart failure, with the updated meta-analysis showing an 11% reduction

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