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Histamine intolerance or rather, overall high histamine levels could be an additive factor for the above conditions

PubMed ID: 37952131

(2015) noted improved performance and reduced perceived exertion in athletes taking citrulline-based supplements

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Moreover, a randomized, evaluator-blinded clinical trial including 40 Brazilian women with facial melasma who underwent broad-spectrum tinted sunscreen and nightly application of 5% cysteamine or 4% HQ for 16 weeks resulted in an MASI reduction of 32% and 52%, respectively [31]