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2020 Jul;374(1):74-83

Additional signaling processes may involve calcium flux, kinase activation, and transcriptional changes that alter metabolic enzyme expression and neuroendocrine signaling networks

The opioid receptor hypothesis A separate line of work proposed that DSIP possesses agonist activity at opiate receptors a hypothesis explicit in the title of the principal human withdrawal paper, which describes DSIP as a neuropeptide with potential agonistic activity on opiate receptors. [13] Supporting animal evidence came from Scherschlichts group, where DSIP at 25.5 mcg/kg IV attenuated naloxone-precipitated withdrawal jumping in morphine-dependent mice