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More polymorphisms of GSTP1 and associated cancer risks are shown in the next table: Source: (GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)) Therefore, xenobiotics can not only overload the GST detoxification processes, but they can damage GST and the enzymes it encodes, like GSTP1

However, it is also important to note that many eligible patients are not prescribed or do not have access to guideline-recommended drug therapies in the first place, which presents another challenge to optimizing treatment for patients with CKD and T2D

Sjstrm CD, Johansson P, Ptaszynska A, List J, Johnsson E

State licensing exclusions appear in reviews

That difference shows up in the safety conversation