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Lopes D, et al

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Tirzepatide also shows stronger improvements in insulin sensitivity and liver fat

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The tissue-specific activities are regulated by the interaction of many signalling pathways, notably the cAMP/PKA and PI3K/Akt pathways, which together mediate GLP-1's metabolic and protective effects

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This suggests that the improvements in metabolic parameters were primarily driven by the modulation of lipid and glucose metabolism, rather than the suppression of inflammation

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