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In the pivotal STRATUM trial, nearly 80% of individuals achieved the primary efficacy endpoint of Investigators Global Assessment (IGA) Success, with just over 50% reaching complete clearance at week 8

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In some embodiments, any formulation or composition described herein has a pH that allows for sterilization (e.g., by filtration or aseptic mixing or heat treatment and/or autoclaving (e.g., terminal sterilization)) of a formulation or composition without degradation of the therapeutic agent