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and Yamamoto et al

Recent studies on Citrus aurantium indicate that the hexane fraction of CA (HFCA) stimulates NCI-H716 cells and induces membrane depolarization in NCI-H716, resulting in the secretion of glucagon-like peptide-1 (GLP-1), which regulates insulin secretion in pancreatic beta-cells

Allergic Responses: Some individuals may experience allergic reactions to GLP-1 medications, which can range from mild to severe

Consequently, Schulzs groundbreaking observations of a biphasic, stimulatory-inhibitory response were largely dismissed by his contemporaries as experimental anomalies, delaying the formal recognition of hormesis for decades

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