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The injectable form was placed on the FDA's Category 2 bulk drug substances list in 2023, restricting compounding pharmacies from preparing it under Section 503A

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doi: 10.1002/bab.1860 28 LeeSYJungYORyuJGOhHJSonHJLeeSHet al

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Active processes such as osteoclast activity leading to bone and cartilage resorption, synoviocyte proliferation with infiltration, and multiplication of immune cells leading to pannus formation increase the energy demand and thus alter cellular metabolism in the affected joint

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