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Systems Integration: Optimizing Population Benefits over Harms Population net exposure to harmful toxicants depends on the actual patterns and prevalence of product use that vary along the continuum of harm (Figures 1 and 2), as well as keeping as many non-users as possible, especially youth, from any use of nicotine

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However, in finalizing the rules, the agency must stay vigilant to prevent tobacco companies from thwarting these measures

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A 6-month inhalation toxicology study in Apoe(-/-) mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract