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Common warning signs of a serious alcohol and drug interaction include: Extreme drowsiness or inability to stay awake Confusion or disorientation Slurred speech Impaired coordination or difficulty walking Slow, shallow, or irregular breathing Loss of consciousness Seizures Chest pain or irregular heartbeat Severe dizziness or fainting Persistent vomiting The risk of serious complications increases when alcohol is combined with central nervous system depressants such as benzodiazepines, opioids, or certain sleep medications