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Buniello A, MacArthur JAL, Cerezo M, Harris LW, Hayhurst J, Malangone C, et al

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In their reporting on a 2025 study from the Journal of the American College of Cardiology (JACC), Medscape summed up, Compared with people who said they did not use cannabis, those who reported using the drug had a sixfold increased risk for heart attack, a fourfold increased risk for ischemic stroke, double the risk for heart failure, and three times the risk for cardiovascular death, heart attack, or stroke [10]

For both sexes, the mean age at which smokers started to smoke decreased with each successive decade of birth, from 23.4 years for men born before 1890 to 19.8 years for those born during 1940-45, and from 36.0 years for women born before 1890 to 24.3 years for women born during 1940-45 (fig 1)