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Vol 38 Lyon, France: IARC pp

[22] More recent excavations indicate the cannabis used in the most ancient burials were devoid of THC, while significantly stronger psychoactive cannabis was employed at least 2,500 years ago in the Pamir Mountains

Nicotine exposure during adolescence can be long-lasting and may result in lower attention, impulse control, mood disorders, and addiction Some e-cigarette products can contain as much nicotine as a pack of 20 regular cigarettes E-cigarettes can cause unintended injuries from fires and explosions caused by defective e-cigarette batteries

They used a technique called Mendelian randomization to see whether smoking causes increased body fat