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The obtained data suggest that the pineal gland is important for normalizing the circadian signal needed for gonadoliberin release

The clinical significance of this effect is not fully characterized, but some providers recommend that women on oral contraceptives switch to a non-oral method (patch, ring, IUD, implant) when starting GLP-1 therapy, or use backup contraception during the titration period

Glucagon-like peptide-1 receptor (GLP-1R) is one of the most successful drug targets of T2DM and obesity, and its peptidic ligands have been proposed as potential therapeutic agents for NASH

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While significant weight loss can occur during active treatment, the outcomes over time are variable