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Lawmakers might compel certain workersemergency-room doctors, air-traffic controllersto take them

Levine et al

Patients on combination therapy should monitor blood glucose levels regularly and discuss potential dose reductions of insulin or sulfonylureas with their healthcare provider during tirzepatide initiation and dose escalation

Furthermore, reduction in bioavailable NO induces pathogenic vascular smooth muscle cell proliferation in vitro and vasoconstriction in vivo due to suppression of cGMP kinase signaling 40,41