As most patients with type 2 diabetes are treated in the primary-care setting, the increasing utilization of SGLT2 inhibitors and GLP1 agonists by our primary-care colleagues will improve outcomes in people with type 2 diabetes on a population level. The clinical guidelines cautioned against treating people with type 2 diabetes with inadequate glycemic control with dipeptidyl peptidase-4 (DPP-4) inhibitors, saying that high-certainty evidence showed that adding a DPP-4 inhibitor does not reduce morbidity or all-cause mortality.
Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease
Hormones are the chemical messengers that tell your body what to do and when
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The mechanism is well-characterized: glutathione inhibits tyrosinase activity, reduces eumelanin (dark pigment) production, and promotes pheomelanin (lighter pigment) synthesis
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