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The size of the adaptation on your meta in your metabolism tends to track with the size of the deficit, how much fast you lose, fat you lose, and the duration

These changes are generally transient and manageable

It is to restore a more stable physiological state, one that supports resilience, function, and the kind of long-term healthspan that the biology of menopause, left unaddressed, progressively erodes

After an hour of stirring at r.t., the solvent was removed under vacuum, the residue stirred in hexane-ether (9 : 1 v/v), and the precipitate filtered off