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Additionally, LDLR gene expression was independently elevated by thapsigargin, an endoplasmic reticulum stress inducer known to activate SREBP-2, and AICAR, an AMPK agonist (Fig

doi: 10.3389/fimmu.2026.1791087 Received 19 January 2026 Revised 13 March 2026 Accepted 13 March 2026 Published 31 March 2026 Volume 17 - 2026 Edited by Matteo Ripa, Nottingham University Hospitals NHS Trust, United Kingdom Reviewed by Miguel Seabra, Imperial College London, United Kingdom Neetu Kushwah, Boston Childrens Hospital and Harvard Medical School, United States Updates Copyright 2026 Zhu, Lin, Han, Cao, Zhu, Shi, Deng, Li, Yang and Lu

We used ANCOVA analysis with adjustment for age, sex, ethnicity and smoking status to observe differences among the three groups

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Our results show that the interactions between P9 and ICAM-2 could be targeted by therapeutics for metabolic diseases