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The overall proposed effect is lower blood-pressure burden, reduced endothelial stress, and support for cardiovascular health

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Acute GH stimulation by secretagogues can induce transient sodium and water retention through modulation of renal function. Johannsson , Journal of Clinical Endocrinology & Metabolism Prolactin Elevation GHRP-6 is associated with a higher risk of prolactin elevation than GHRP-2: Elevated prolactin can contribute to gynecomastia , libido suppression , or mood disturbances in sensitive individuals

I dont see why its effects on thyroid would change due to the route but who knows

Psilocybin treatment extends cellular lifespan and improves survival of aged mice